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The Tissue Plasminogen Activator-Plasminogen Proteolytic Cascade Accelerates Amyloid-β (Aβ) Degradation and Inhibits Aβ-Induced Neurodegeneration
Accumulation of the amyloid-β (Aβ) peptide depends on both its generation and clearance. To better define clearance pathways, we have evaluated the role of the tissue plasminogen activator (tPA)-plasmin system in Aβ degradation in vivo. In two different mouse models of Alzheimer's disease, chro...
Bewaard in:
| Gepubliceerd in: | J Neurosci |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Society for Neuroscience
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6740393/ https://ncbi.nlm.nih.gov/pubmed/14523088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-26-08867.2003 |
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