Low-frequency variants at the CYP2C9 locus among Puerto Rican patients on warfarin: in silico predictions of functionality and conservation

AIM: Perform in silico predictions of functional consequences of CYP2C9 variants identified by next-generation sequencing in Puerto Ricans. METHODS: Identified low-frequency CYP2C9 variants (minor allele frequencies <2%) were evaluated using the Combined Annotation-Dependent Depletion (CADD v1.3)...

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發表在:Pharmacogenomics
Main Authors: Claudio-Campos, Karla, Moneró-Paredes, Mariangeli, Hernández, Eliud, Renta, Jessicca, Duconge, Jorge
格式: Artigo
語言:Inglês
出版: Future Medicine Ltd 2019
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739902/
https://ncbi.nlm.nih.gov/pubmed/31453773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2019-0051
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