Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation

Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a CRISPR screen, to identify host factors required for norovir...

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Pubblicato in:eLife
Autori principali: Hosmillo, Myra, Lu, Jia, McAllaster, Michael R, Eaglesham, James B, Wang, Xinjie, Emmott, Edward, Domingues, Patricia, Chaudhry, Yasmin, Fitzmaurice, Tim J, Tung, Matthew KH, Panas, Marc Dominik, McInerney, Gerald, Locker, Nicolas, Wilen, Craig B, Goodfellow, Ian G
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Microbiology and Infectious Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739877/
https://ncbi.nlm.nih.gov/pubmed/31403400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46681
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