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Suppression of Notch signaling in osteoclasts improves bone regeneration and healing

Owing to the central role of osteoclasts in bone physiology and remodeling, manipulation of their maturation process provides a potential therapeutic strategy for treating bone diseases. To investigate this, we genetically inhibited the Notch signaling pathway in the myeloid lineage, which includes...

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Foilsithe in:J Orthop Res
Main Authors: Goel, Peeyush N, Moharrer, Yasaman, Hebb, John H, Egol, Alexander J, Kaur, Gurpreet, Hankenson, Kurt D, Ahn, Jaimo, Ashley, Jason W
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739141/
https://ncbi.nlm.nih.gov/pubmed/31166033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.24384
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