Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection

The interferon (IFN) pathway plays an essential role in the innate immune response following viral infections and subsequent shaping of adaptive immunity. Infections with influenza A viruses (IAV) activate the IFN pathway after the recognition of pathogen-specific molecular patterns by respective pa...

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Veröffentlicht in:J Innate Immun
Hauptverfasser: Hatesuer, Bastian, Hoang, Hang Thi Thu, Riese, Peggy, Trittel, Stephanie, Gerhauser, Ingo, Elbahesh, Husni, Geffers, Robert, Wilk, Esther, Schughart, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: S. Karger AG 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738875/
https://ncbi.nlm.nih.gov/pubmed/27811478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000450705
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