Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition

Natural killer (NK) cells are innate lymphocytes that aid in self-nonself discrimination by recognizing cells undergoing pathological alterations. The NKR-P1B inhibitory receptor recognizes Clr-b, a self-encoded marker of cell health downregulated during viral infection. Here, we show that Clr-b los...

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Detalhes bibliográficos
Publicado no:J Innate Immun
Main Authors: Kirkham, Christina L., Aguilar, Oscar A., Yu, Tao, Tanaka, Miho, Mesci, Aruz, Chu, Kuan-Lun, Fine, Jason H., Mossman, Karen L., Bremner, Rod, Allan, David S.J., Carlyle, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738865/
https://ncbi.nlm.nih.gov/pubmed/28288457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000454926
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