In vivo Lipopolysaccharide Tolerance Recruits CD11b(+) Macrophages to the Liver with Enhanced Bactericidal Activity and Low Tumor Necrosis Factor-Releasing Capability, Resulting in Drastic Resistance to Lethal Septicemia

OBJECTIVES: In vivo lipopolysaccharide (LPS) tolerance on bacterial infection was investigated, focusing on liver macrophages. METHODS: LPS tolerance was induced by intraperitoneal injections with 5 μg/kg of LPS for 3 consecutive days, and then mice were intravenously infected with Escherichia coli....

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Detalhes bibliográficos
Publicado no:J Innate Immun
Main Authors: Kinoshita, Manabu, Miyazaki, Hiromi, Nakashima, Hiroyuki, Nakashima, Masahiro, Nishikawa, Makoto, Ishikiriyama, Takuya, Kato, Shoichiro, Iwaya, Keiichi, Hiroi, Sadayuki, Shinomiya, Nariyoshi, Seki, Shuhji
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738816/
https://ncbi.nlm.nih.gov/pubmed/28675904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000475931
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