Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases

BACKGROUND: Claudin-18 (CLDN18) is a highly specific tight junction protein of the gastric mucosa. An isoform of CLDN18, the Claudin 18.2, has recently emerged as an innovative drug target for metastatic gastric cancer. METHODS: We investigated the immunohistochemical profile of CLDN18, p53, p16, E-...

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Bibliografiske detaljer
Udgivet i:Br J Cancer
Main Authors: Coati, Irene, Lotz, Gábor, Fanelli, Giuseppe Nicolò, Brignola, Stefano, Lanza, Cristiano, Cappellesso, Rocco, Pellino, Antonio, Pucciarelli, Salvatore, Spolverato, Gaya, Guzzardo, Vincenza, Munari, Giada, Zaninotto, Giovanni, Scarpa, Marco, Mastracci, Luca, Farinati, Fabio, Realdon, Stefano, Pilati, Pierluigi, Lonardi, Sara, Valeri, Nicola, Rugge, Massimo, Kiss, Andras, Loupakis, Fotios, Fassan, Matteo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738069/
https://ncbi.nlm.nih.gov/pubmed/31235864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0508-4
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