WNT/β-catenin modulates the axial identity of embryonic stem cell-derived human neural crest

WNT/β-catenin signaling is crucial for neural crest (NC) formation, yet the effects of the magnitude of the WNT signal remain ill-defined. Using a robust model of human NC formation based on human pluripotent stem cells (hPSCs), we expose that the WNT signal modulates the axial identity of NCs in a...

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Detalles Bibliográficos
Publicado en:Development
Autores principales: Gomez, Gustavo A., Prasad, Maneeshi S., Wong, Man, Charney, Rebekah M., Shelar, Patrick B., Sandhu, Nabjot, Hackland, James O. S., Hernandez, Jacqueline C., Leung, Alan W., García-Castro, Martín I.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2019
Materias:
Human Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737904/
https://ncbi.nlm.nih.gov/pubmed/31399472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.175604
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