Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y(2) receptor antagonist

Extracellular nucleotides mediate multiple physiological effects such as proliferation, differentiation, or induction of apoptosis through G protein–coupled P2Y receptors or P2X ion channels. Evaluation of the complete physiological role of nucleotides has long been hampered by a lack of potent and...

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Publicat a:Purinergic Signal
Autors principals: Brockmann, Nicole, Sureechatchaiyan, Parichat, Müller, David, Hennicke, Tatiana, Hausmann, Ralf, Fritz, Gerhard, Hamacher, Alexandra, Kassack, Matthias U.
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2019
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737154/
https://ncbi.nlm.nih.gov/pubmed/31270713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-019-09663-4
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