Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories

Cardiosphere-derived cells (CDCs) are therapeutic candidates with disease-modifying bioactivity, but their variable potency has complicated their clinical translation. Transcriptomic analyses of CDCs from human donors have revealed that the therapeutic potency of these cells correlates with Wnt/β-ca...

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Detalhes bibliográficos
Publicado no:Nat Biomed Eng
Main Authors: Ibrahim, Ahmed G.E., Li, Chang, Rogers, Russel, Fournier, Mario, Li, Liang, Vaturi, Sharon D., Antes, Travis, Sanchez, Lizbeth, Akhmerov, Akbarshakh, Moseley, Jennifer Johnson, Tobin, Brooke, Rodriguez-Borlado, Luis, Smith, Rachel R., Marbán, Linda, Marbán, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736698/
https://ncbi.nlm.nih.gov/pubmed/31451800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-019-0448-6
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