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Probing Metal Ion Discrimination in a Protein Designed to Bind Uranyl Cation With Femtomolar Affinity

The design of metal-binding sites in proteins that combine high affinity with high selectivity for the desired metal ion remains a challenging goal. Recently, a protein designed to display femtomolar affinity for [Formula: see text] , dubbed “Super Uranyl-binding Protein” (SUP), was described, with...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Hoarau, Marie, Koebke, Karl J., Chen, Zhan, Marsh, E. Neil G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736553/
https://ncbi.nlm.nih.gov/pubmed/31552264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00073
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