N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels

AIMS: Elevated apolipoprotein C-III (apoC-III) levels are associated with hypertriglyceridaemia and coronary heart disease. AKCEA-APOCIII-L(Rx) is an N-acetyl galactosamine-conjugated antisense oligonucleotide targeted to the liver that selectively inhibits apoC-III protein synthesis. METHODS AND RE...

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Bibliographic Details
Published in:Eur Heart J
Main Authors: Alexander, Veronica J, Xia, Shuting, Hurh, Eunju, Hughes, Steven G, O’Dea, Louis, Geary, Richard S, Witztum, Joseph L, Tsimikas, Sotirios
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Fast Track Clinical Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736334/
https://ncbi.nlm.nih.gov/pubmed/31329855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehz209
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