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Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleo...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Cell Oncol |
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| Κύριοι συγγραφείς: | , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Taylor & Francis
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6736317/ https://ncbi.nlm.nih.gov/pubmed/31528687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1536843 |
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