CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration

Background: Peripheral nerve regeneration requires coordinated functions of neurotrophic factors and neuronal cells. CRISPR activation (CRISPRa) is a powerful tool that exploits inactive Cas9 (dCas9), single guide RNA (sgRNA) and transcription activator for gene activation, but has yet to be harness...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Hsu, Mu-Nung, Liao, Han-Tsung, Truong, Vu Anh, Huang, Kai-Lun, Yu, Fu-Jen, Chen, Hwei-Hsien, Nguyen, Thi Kieu Nuong, Makarevich, Pavel, Parfyonova, Yelena, Hu, Yu-Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735509/
https://ncbi.nlm.nih.gov/pubmed/31534539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.36790
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