Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice

Endothelial and mesenchymal stromal cells (ECs/MSCs) are crucial components of hematopoietic bone marrow stem cell niches. Both cell types appear to be required to support the maintenance and expansion of multipotent hematopoietic cells, i.e. hematopoietic stem cells (HSCs) and multipotent progenito...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Radtke, Stefan, Görgens, André, da Conceição Castro, Symone Vitoriano, Kordelas, Lambros, Köninger, Angela, Dürig, Jan, Möllmann, Michael, Horn, Peter A., Giebel, Bernd
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733927/
https://ncbi.nlm.nih.gov/pubmed/31501490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49221-x
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