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Molecular Basis of BioJ, a Unique Gatekeeper in Bacterial Biotin Synthesis
Biotin is an indispensable cofactor in the three domains of life. The unusual virulence factor BioJ of Francisella catalyzes the formation of pimeloyl-ACP, an intermediate in biotin synthesis. Here, we report the 1.58 Å crystal structure of BioJ, the enzymatic activity of which is determined with th...
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| Publicado no: | iScience |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6733898/ https://ncbi.nlm.nih.gov/pubmed/31494495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.08.028 |
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