Comparison of bulk and microfluidics methods for the formulation of poly-lactic-co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures

The efficient and reproducible production of nanoparticles using bulk nanoprecipitation methods is still challenging because of low batch to batch reproducibility. Here, we optimize a bulk nanoprecipitation method using design of experiments and translate to a microfluidic device to formulate surfac...

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Pubblicato in:Int J Pharm X
Autori principali: Streck, Sarah, Neumann, Henriette, Nielsen, Hanne Mørck, Rades, Thomas, McDowell, Arlene
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733288/
https://ncbi.nlm.nih.gov/pubmed/31517295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpx.2019.100030
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