In vitro–in vivo evaluation of chitosan-PLGA nanoparticles for potentiated gastric retention and anti-ulcer activity of diosmin

BACKGROUND: Diosmin showed poor water solubility and low bioavailability. Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles were successfully used to improve the drugs solubility and bioavailability. Coating of PLGA nanoparticles with chitosan can ameliorate their gastric retention and cellular up...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Abd El Hady, Walaa Ebrahim, Mohamed, Elham Abdelmonem, Soliman, Osama Abd El-Aazeem, EL-Sabbagh, Hassan Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732519/
https://ncbi.nlm.nih.gov/pubmed/31564873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S213836
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