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Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

Salmonella Typhi activates the host DNA damage response through the typhoid toxin, facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA damage response, which we call RING (response induced by a genotoxin), characterized by accumulation of phosphorylated histone H...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Ibler, Angela E. M., ElGhazaly, Mohamed, Naylor, Kathryn L., Bulgakova, Natalia A., F. El-Khamisy, Sherif, Humphreys, Daniel
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731267/
https://ncbi.nlm.nih.gov/pubmed/31492859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12064-1
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