Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

Salmonella Typhi activates the host DNA damage response through the typhoid toxin, facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA damage response, which we call RING (response induced by a genotoxin), characterized by accumulation of phosphorylated histone H...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ibler, Angela E. M., ElGhazaly, Mohamed, Naylor, Kathryn L., Bulgakova, Natalia A., F. El-Khamisy, Sherif, Humphreys, Daniel
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731267/
https://ncbi.nlm.nih.gov/pubmed/31492859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12064-1
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