Global Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains

Huntington's disease is caused by a polyglutamine repeat expansion in the huntingtin protein which affects the function and folding of the protein, and results in intracellular protein aggregates. Here, we examined whether this mutation leads to altered ubiquitination of huntingtin and other pr...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Sap, Karen A., Guler, Arzu Tugce, Bezstarosti, Karel, Bury, Aleksandra E., Juenemann, Katrin, Demmers, Jeroen A. A., Reits, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731087/
https://ncbi.nlm.nih.gov/pubmed/31138642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001486
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