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Cross-linking Proteomics Indicates Effects of Simvastatin on the TLR2 Interactome and Reveals ACTR1A as a Novel Regulator of the TLR2 Signal Cascade

Toll-like receptor 2 (TLR2) is a pattern recognition receptor that, upon ligation by microbial molecules, interacts with other proteins to initiate pro-inflammatory responses by the cell. Statins (hydroxymethylglutaryl coenzyme A reductase inhibitors), drugs widely prescribed to reduce hypercholeste...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Kamal, Abu Hena Mostafa, Aloor, Jim J., Fessler, Michael B., Chowdhury, Saiful M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731082/
https://ncbi.nlm.nih.gov/pubmed/31221720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001377
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