A1 Adenosine Receptor Upregulation and Activation Attenuates Neuroinflammation and Demyelination in a Model of Multiple Sclerosis

The neuromodulator adenosine regulates immune activation and neuronal survival through specific G-protein-coupled receptors expressed on macrophages and neurons, including the A1 adenosine receptor (A1AR). Here we show that A1AR null (A1AR(-/-)) mice developed a severe progressive-relapsing form of...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Tsutsui, Shigeki, Schnermann, Jurgen, Noorbakhsh, Farshid, Henry, Scot, Yong, V. Wee, Winston, Brent W., Warren, Kenneth, Power, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730323/
https://ncbi.nlm.nih.gov/pubmed/14960625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4271-03.2004
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