Behavioral State Instability in Orexin Knock-Out Mice

Narcolepsy is caused by a lack of orexin (hypocretin), but the physiologic process that underlies the sleepiness of narcolepsy is unknown. Using orexin knock-out (KO) mice as a model of narcolepsy, we critically tested the three leading hypotheses: poor circadian control of sleep and wakefulness, in...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Mochizuki, Takatoshi, Crocker, Amanda, McCormack, Sarah, Yanagisawa, Masashi, Sakurai, Takeshi, Scammell, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2004
Assuntos:
Behavioral/Systems/Cognitive
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729542/
https://ncbi.nlm.nih.gov/pubmed/15254084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0586-04.2004
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