Interleukin-1β Induces a Reactive Astroglial Phenotype via Deactivation of the Rho GTPase–Rock Axis

The cytokine interleukin-1β (IL-1β) is critical to the formation of an astrocytic scar after CNS injury, but the mechanisms by which it induces a reactive phenotype remain unresolved. Here, we show that IL-1β regulates the phenotype of astrocytes via deactivation of the Rho GTPase–Rho kinase (ROCK)...

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Publicat a:J Neurosci
Autors principals: John, Gareth R., Chen, Lanfen, Rivieccio, Mark A., Melendez-Vasquez, Carmen V., Hartley, Adam, Brosnan, Celia F.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2004
Matèries:
Cellular/Molecular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729504/
https://ncbi.nlm.nih.gov/pubmed/15028778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4789-03.2004
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