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Mutations in Caenorhabditis elegans Cytoplasmic Dynein Components Reveal Specificity of Neuronal Retrograde Cargo

We describe Caenorhabditis elegans dynein complex mutants, which misaccumulate synaptic proteins at the ends of neuronal processes. Ultrastructural analysis revealed irregularly sized vesicles that likely represent accumulation of cargo. We propose that synaptobrevin, synaptotagmin, and UNC-104 are...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Koushika, Sandhya P., Schaefer, Anneliese M., Vincent, Rose, Willis, John H., Bowerman, Bruce, Nonet, Michael L.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2004
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729415/
https://ncbi.nlm.nih.gov/pubmed/15102906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5039-03.2004
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