Catechol-O-Methyltransferase Inhibition Improves Set-Shifting Performance and Elevates Stimulated Dopamine Release in the Rat Prefrontal Cortex

The Val(158)Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex (PFC); however, although catecholaminergic neurotransmission is implicated, the underlying mechanisms remain elusive be...

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Pubblicato in:J Neurosci
Autori principali: Tunbridge, E. M., Bannerman, D. M., Sharp, T., Harrison, P. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2004
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729311/
https://ncbi.nlm.nih.gov/pubmed/15190105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1124-04.2004
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