Impact of antibiotic therapy on the development and response to treatment of immune checkpoint inhibitor-mediated diarrhea and colitis

BACKGROUND: The gut microbiome impacts the efficacy of immune checkpoint inhibitor (ICI) therapy and the development of ICI-mediated diarrhea and/or colitis (IMDC). Antibiotic therapy,especially that with anaerobic activity, has profound effects on the gut microbiome. Therefore, we sought to assess...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Abu-Sbeih, Hamzah, Herrera, Lauren Nicholas, Tang, Tenglong, Altan, Mehmet, Chaftari, Anne-Maria P., Okhuysen, Pablo C., Jenq, Robert R., Wang, Yinghong
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729015/
https://ncbi.nlm.nih.gov/pubmed/31488205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0714-x
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