Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis

BACKGROUND: Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic cell proliferation and survival. Key transcription factors that are negatively re...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Lu, Miao, Hartmann, Daniel, Braren, Rickmer, Gupta, Aayush, Wang, Baocai, Wang, Yang, Mogler, Carolin, Cheng, Zhangjun, Wirth, Thomas, Friess, Helmut, Kleeff, Jörg, Hüser, Norbert, Sunami, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728971/
https://ncbi.nlm.nih.gov/pubmed/31488102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6110-6
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