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Deep learning extends de novo protein modelling coverage of genomes using iteratively predicted structural constraints

The inapplicability of amino acid covariation methods to small protein families has limited their use for structural annotation of whole genomes. Recently, deep learning has shown promise in allowing accurate residue-residue contact prediction even for shallow sequence alignments. Here we introduce...

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Vydáno v:Nat Commun
Hlavní autoři: Greener, Joe G., Kandathil, Shaun M., Jones, David T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726615/
https://ncbi.nlm.nih.gov/pubmed/31484923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11994-0
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