Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.

Genetic influences on alcohol and drug dependence partially overlap, however specific loci underlying this overlap remain unclear. We conducted a genome-wide association study (GWAS) of a phenotype representing alcohol or illicit drug dependence (ANYDEP) among 7,291 European-Americans (EA; 2,927 cas...

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Published in:Genes Brain Behav
Main Authors: Wetherill, Leah, Lai, Dongbing, Johnson, Emma C., Anokhin, Andrey, Bauer, Lance, Bucholz, Kathleen K., Dick, Danielle M., Hariri, Ahmad R., Hesselbrock, Victor, Kamarajan, Chella, Kramer, John, Kuperman, Samuel, Meyers, Jacquelyn L., Nurnberger, John I., Schuckit, Marc, Scott, Denise M., Taylor, Robert E., Tischfield, Jay, Porjesz, Bernice, Goate, Alison M., Edenberg, Howard J., Foroud, Tatiana, Bogdan, Ryan, Agrawal, Arpana
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726116/
https://ncbi.nlm.nih.gov/pubmed/31099175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gbb.12580
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