Deletion of the Prostaglandin E(2) EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease

Epidemiological studies demonstrate that chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) in normal aging populations reduces the risk of developing Alzheimer's disease (AD). NSAIDs inhibit the enzymatic activity of cyclooxygenase-1 (COX-1) and inducible COX-2, which catalyze the fi...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Liang, Xibin, Wang, Qian, Hand, Tracey, Wu, Liejun, Breyer, Richard M., Montine, Thomas J., Andreasson, Katrin
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2005
Subjects:
Neurobiology of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725803/
https://ncbi.nlm.nih.gov/pubmed/16267225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3591-05.2005
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