GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum

GABA transporter subtype 1 (GAT1) knock-out (KO) mice display normal reproduction and life span but have reduced body weight (female, -10%; male, -20%) and higher body temperature fluctuations in the 0.2-1.5/h frequency range. Mouse GAT1 (mGAT1) KO mice exhibit motor disorders, including gait abnorm...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Chiu, Chi-Sung, Brickley, Stephen, Jensen, Kimmo, Southwell, Amber, Mckinney, Sheri, Cull-Candy, Stuart, Mody, Istvan, Lester, Henry A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2005
Schlagworte:
Neurobiology of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725086/
https://ncbi.nlm.nih.gov/pubmed/15788781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3364-04.2005
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