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Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol

Previous studies in yeast showed that mitochondrial stressors not directly targeting the protein import machinery can cause mitochondrial precursor overaccumulation stress (mPOS) in the cytosol independent of bioenergetics. Here, we demonstrate mPOS and stress responses in human cells. We show that...

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Detaylı Bibliyografya
Yayımlandı:Mol Biol Cell
Asıl Yazarlar: Liu, Yaxin, Wang, Xiaowen, Coyne, Liam P., Yang, Yuan, Qi, Yue, Middleton, Frank A., Chen, Xin Jie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Cell Biology 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724602/
https://ncbi.nlm.nih.gov/pubmed/30893019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-01-0046
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