First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain–Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids

Both synthetic and endogenous glucocorticoids are important pharmaceutic drugs known to bind to the ligand-binding domain (LBD) of glucocorticoid receptor (GR), a member of the nuclear receptor (NR) superfamily. Ligand binding induces conformational changes within GR, resulting in subsequent DNA bin...

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Bibliografiska uppgifter
I publikationen:Mol Pharmacol
Huvudupphovsmän: Liu, Xu, Wang, Yashuo, Ortlund, Eric A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2019
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724573/
https://ncbi.nlm.nih.gov/pubmed/31391291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.116806
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