Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability

Genetic activation of the class I PI3K pathway is very common in cancer. This mostly results from oncogenic mutations in PIK3CA, the gene encoding the ubiquitously expressed PI3Kα catalytic subunit, or from inactivation of the PTEN tumour suppressor, a lipid phosphatase that opposes class I PI3K sig...

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書目詳細資料
發表在:Biomolecules
Main Authors: Vanhaesebroeck, Bart, Bilanges, Benoit, Madsen, Ralitsa R., Dale, Katie L., Lau, Evelyn, Vladimirou, Elina
格式: Artigo
語言:Inglês
出版: MDPI 2019
主題:
Review
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6723836/
https://ncbi.nlm.nih.gov/pubmed/31374965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9080331
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