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Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development

The development of stable solid dispersion formulations that maintain desired improvement of drug dissolution rate during the entire shelf life requires the analysis of drug-polymer solubility and miscibility. Only if the drug concentration is below the solubility limit in the polymer, the physical...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Medarević, Djordje, Djuriš, Jelena, Barmpalexis, Panagiotis, Kachrimanis, Kyriakos, Ibrić, Svetlana
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722809/
https://ncbi.nlm.nih.gov/pubmed/31374926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11080372
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