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Valproate inhibits glucose-stimulated insulin secretion in beta cells
Valproate (VPA), an FDA approved anti-epileptic drug with a half-life of 12–18h in humans, has been shown to perturb the vacuolar proton pump (vH(+)-ATPase) function in yeasts by inhibiting myo-inositol phosphate synthase, the first and rate-limiting enzyme in inositol biosynthesis, thereby resultin...
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| Veröffentlicht in: | Histochem Cell Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6719693/ https://ncbi.nlm.nih.gov/pubmed/30145684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00418-018-1713-6 |
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