Valproate inhibits glucose-stimulated insulin secretion in beta cells

Valproate (VPA), an FDA approved anti-epileptic drug with a half-life of 12–18h in humans, has been shown to perturb the vacuolar proton pump (vH(+)-ATPase) function in yeasts by inhibiting myo-inositol phosphate synthase, the first and rate-limiting enzyme in inositol biosynthesis, thereby resultin...

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Bibliographic Details
Published in:Histochem Cell Biol
Main Authors: Yedulla, Nikhil R., Naik, Akshata R., Kokotovich, Keith M., Yu, Wenxi, Greenberg, Miriam L., Jena, Bhanu P.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719693/
https://ncbi.nlm.nih.gov/pubmed/30145684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00418-018-1713-6
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