NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing

NK cells eliminate virus-infected and tumor cells by releasing cytotoxic granules containing granzyme B (GrzB) or by engaging death receptors that initiate caspase cascades. The orchestrated interplay between both cell death pathways remains poorly defined. Here we simultaneously measure the activit...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Prager, Isabel, Liesche, Clarissa, van Ooijen, Hanna, Urlaub, Doris, Verron, Quentin, Sandström, Niklas, Fasbender, Frank, Claus, Maren, Eils, Roland, Beaudouin, Joël, Önfelt, Björn, Watzl, Carsten
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719417/
https://ncbi.nlm.nih.gov/pubmed/31270246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181454
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