OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo

Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g. KPC-2) and loss or modification of the major non-selective porins OmpK35 and OmpK36. However, the mechanism underpinning OmpK36-mediated resistance and consequences of these changes on pathoge...

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Publicat a:Nat Commun
Autors principals: Wong, Joshua L. C., Romano, Maria, Kerry, Louise E., Kwong, Hok-Sau, Low, Wen-Wen, Brett, Stephen J., Clements, Abigail, Beis, Konstantinos, Frankel, Gad
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718652/
https://ncbi.nlm.nih.gov/pubmed/31477712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11756-y
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