A randomized phase II trial of nab‐paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer

PURPOSE: Notch signaling dysregulation is implicated in the development of pancreatic adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that inhibits Notch2/3 receptors. PATIENTS AND METHODS: Aphase 2, randomized, placebo‐controlled, multicenter trial evaluated the activity of tarextu...

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Publicado en:Cancer Med
Autores principales: Hu, Zishuo Ian, Bendell, Johanna C., Bullock, Andrea, LoConte, Noelle K., Hatoum, Hassan, Ritch, Paul, Hool, Hugo, Leach, Joseph W., Sanchez, James, Sohal, Davendra P. S., Strickler, John, Patel, Ravindranath, Wang‐Gillam, Andrea, Firdaus, Irfan, Yu, Kenneth H., Kapoun, Ann M., Holmgren, Eric, Zhou, Lei, Dupont, Jakob, Picozzi, Vincent, Sahai, Vaibhav, O'Reilly, Eileen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
Materias:
Clinical Cancer Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718621/
https://ncbi.nlm.nih.gov/pubmed/31347292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2425
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