Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors

The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl acyltransferase, whose depletion reduced palmitoylat...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gorinski, Nataliya, Bijata, Monika, Prasad, Sonal, Wirth, Alexander, Abdel Galil, Dalia, Zeug, Andre, Bazovkina, Daria, Kondaurova, Elena, Kulikova, Elizabeth, Ilchibaeva, Tatiana, Zareba-Koziol, Monika, Papaleo, Francesco, Scheggia, Diego, Kochlamazashvili, Gaga, Dityatev, Alexander, Smyth, Ian, Krzystyniak, Adam, Wlodarczyk, Jakub, Richter, Diethelm W., Strekalova, Tatyana, Sigrist, Stephan, Bang, Claudia, Hobuß, Lisa, Fiedler, Jan, Thum, Thomas, Naumenko, Vladimir S., Pandey, Ghanshyam, Ponimaskin, Evgeni
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718429/
https://ncbi.nlm.nih.gov/pubmed/31477731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11876-5
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados