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Oxidation-induced destabilization of the fibrinogen αC-domain dimer investigated by molecular dynamics simulations
Upon activation, fibrinogen is converted to insoluble fibrin, which assembles into long strings called protofibrils. These aggregate laterally to form a fibrin matrix that stabilizes a blood clot. Lateral aggregation of protofibrils is mediated by the αC domain, a partially structured fragment locat...
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| Veröffentlicht in: | Proteins |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6718331/ https://ncbi.nlm.nih.gov/pubmed/31134660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25746 |
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