Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha

Folates are critical for central nervous system function. Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRα/Folr1), known to be regulated by ligand-activated nuclear receptors. Cerebral folate deli...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Alam, Camille, Aufreiter, Susanne, Georgiou, Constantine J., Hoque, Md. Tozammel, Finnell, Richard H., O’Connor, Deborah L., Goldman, I. David, Bendayan, Reina
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717308/
https://ncbi.nlm.nih.gov/pubmed/31405972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907077116
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