Alternative promoters drive human cytomegalovirus reactivation from latency

Reactivation from latency requires reinitiation of viral gene expression and culminates in the production of infectious progeny. The major immediate early promoter (MIEP) of human cytomegalovirus (HCMV) drives the expression of crucial lytic cycle transactivators but is silenced during latency in he...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Collins-McMillen, Donna, Rak, Mike, Buehler, Jason C., Igarashi-Hayes, Suzu, Kamil, Jeremy P., Moorman, Nathaniel J., Goodrum, Felicia
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717278/
https://ncbi.nlm.nih.gov/pubmed/31409717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900783116
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