TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Aging and chronic inflammation are independent risk factors for the development of atherothrombosis and cardiovascular disease. We hypothesized that aging-associated inflammation promotes the development of platelet hyperreactivity and increases thrombotic risk during aging. Functional platelet stud...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Davizon-Castillo, Pavel, McMahon, Brandon, Aguila, Sonia, Bark, David, Ashworth, Katrina, Allawzi, Ayed, Campbell, Robert A., Montenont, Emilie, Nemkov, Travis, D’Alessandro, Angelo, Clendenen, Nathan, Shih, Lauren, Sanders, Natalie A., Higa, Kelly, Cox, Allaura, Padilla-Romo, Zavelia, Hernandez, Giovanni, Wartchow, Eric, Trahan, George D., Nozik-Grayck, Eva, Jones, Kenneth, Pietras, Eric M., DeGregori, James, Rondina, Matthew T., Di Paola, Jorge
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2019
Sujets:
Plenary Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716075/
https://ncbi.nlm.nih.gov/pubmed/31311815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000200
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