TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Aging and chronic inflammation are independent risk factors for the development of atherothrombosis and cardiovascular disease. We hypothesized that aging-associated inflammation promotes the development of platelet hyperreactivity and increases thrombotic risk during aging. Functional platelet stud...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Davizon-Castillo, Pavel, McMahon, Brandon, Aguila, Sonia, Bark, David, Ashworth, Katrina, Allawzi, Ayed, Campbell, Robert A., Montenont, Emilie, Nemkov, Travis, D’Alessandro, Angelo, Clendenen, Nathan, Shih, Lauren, Sanders, Natalie A., Higa, Kelly, Cox, Allaura, Padilla-Romo, Zavelia, Hernandez, Giovanni, Wartchow, Eric, Trahan, George D., Nozik-Grayck, Eva, Jones, Kenneth, Pietras, Eric M., DeGregori, James, Rondina, Matthew T., Di Paola, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716075/
https://ncbi.nlm.nih.gov/pubmed/31311815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados