Differential Roles of Cysteinyl Cathepsins in TGF-β Signaling and Tissue Fibrosis

Transforming growth factor beta (TGF-β) signaling contributes to tissue fibrosis. Here we demonstrate that TGF-β enhances CatS and CatK expression but reduces CatB and CatL expression in mouse kidney tubular epithelial cells (TECs). CatS- and CatK deficiency reduces TEC nuclear membrane importer imp...

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Publicat a:iScience
Autors principals: Zhang, Xian, Zhou, Yi, Yu, Xueqing, Huang, Qin, Fang, Wenqian, Li, Jie, Bonventre, Joseph V., Sukhova, Galina K., Libby, Peter, Shi, Guo-Ping
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715892/
https://ncbi.nlm.nih.gov/pubmed/31446224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.08.014
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