Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors

Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the order Nidovirales. In this study, we aimed to identify arterivirus proteins involved in th...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: de Wilde, Adriaan H., Boomaars-van der Zanden, A. Linda, de Jong, Anja W. M., Bárcena, Montserrat, Snijder, Eric J., Posthuma, Clara C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714810/
https://ncbi.nlm.nih.gov/pubmed/31243130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00490-19
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