THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report

BACKGROUND: THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has a...

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Bibliografiske detaljer
Udgivet i:BMC Neurol
Main Authors: Kim, Hee Jin, Cho, Hanna, Park, Seongbeom, Jang, Hyemin, Ryu, Young Hoon, Choi, Jae Yong, Moon, Seung Hwan, Oh, Seung Jun, Oh, Minyoung, Na, Duk L., Lyoo, Chul Hyoung, Kim, Eun-Joo, Seeley, William W., Kim, Jae Seung, Choi, Kyung Chan, Seo, Sang Won
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Case Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714095/
https://ncbi.nlm.nih.gov/pubmed/31464590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-019-1434-z
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