Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair

Endochondral ossification during long bone development and natural fracture healing initiates by mesenchymal cell condensation, directed by local morphogen signals and mechanical cues. Here, we aimed to mimic development for regeneration of large bone defects. We hypothesized that engineered human m...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Herberg, S., McDermott, A. M., Dang, P. N., Alt, D. S., Tang, R., Dawahare, J. H., Varghai, D., Shin, J.-Y., McMillan, A., Dikina, A. D., He, F., Lee, Y. B., Cheng, Y., Umemori, K., Wong, P. C., Park, H., Boerckel, J. D., Alsberg, E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713501/
https://ncbi.nlm.nih.gov/pubmed/31489377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax2476
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